Indica and Sativa strains are known to have subjectively different effects on users.
Sativa is known for improving your mood, as well as uplifting, energizing and producing psychoactive effects, also known as a “high”.
Indica is known for being more relaxing and helps with pain. It is also used as a sedative.
Then there are hybrids of the two, which offer a balance of indica and sativa effects.